Case file · CIK 0001224962
Biotech growth capital sample.
Q4 2025 · SEC 13F case file
KOL-style case note
Biotech growth capital sample. This page turns the latest public filing into a shareable research story: what the entity owns, which theme is driving the portfolio, and where to investigate next.
Biotech growth capital sample. It belongs in a smart-money radar because its public 13F shows quarterly capital direction and theme preference.
The latest filing's largest public position is PRAX, around 10.5% of the disclosed 13F portfolio. That is the first place to look for the current thesis.
Mixed is the clearest public theme in the portfolio. The important question is whether that theme repeats across the top positions, not just whether one stock worked.
The latest public portfolio is about $5.6B, with 116 lines and roughly 41.8% in the top 10. Higher concentration means a few decisions can explain more of the proxy return.
This is not a live trading signal. It is a quarterly capital map: start with the ranking, inspect the top holdings, then ask whether the manager has a repeatable framework.
13F filings are delayed and incomplete. They do not show shorts, many derivatives, private positions, cash, or current trade timing. Use this page to generate research questions, not to replace diligence.
Smart Money VelocityVelocity score blends 13F value growth, concentration, theme purity, option exposure, and filing history. It is a prioritization score, not a return.
Score blends filing growth, concentration, theme purity, call exposure, and filing history.
13F value
$5.6BQ4 2025, latest public filingGrowth since first filing
1.35x$4.2B → $5.6BReporting lag13F filings arrive after the quarter ends. The page shows a delayed public snapshot, not live positions.
45dQuarter-end snapshot, not live positionsThis is not actual fund performance. Returns and rankings use public disclosures after they become visible, not private NAV or live trading.
Disclosure workflow
Every number is anchored to a public quarterly filing. The report date is the portfolio snapshot; the filing date is when the market could actually see it.
Public holdings
| Holding | Theme | Type | Value | % |
|---|---|---|---|---|
| PRAXIS PRECISION MEDICINES IPRAX · 1,995,986 shares | Other | SH | $588.3M | 10.5% |
| CELCUITY INCCELC · 3,160,200 shares | Other | SH | $315.2M | 5.6% |
| RHYTHM PHARMACEUTICALS INCRYTM · 2,546,391 shares | Semis | SH | $272.6M | 4.9% |
| ASCENDIS PHARMA A/SASND · 1,081,421 shares | Semis | SH | $230.6M | 4.1% |
| APOGEE THERAPEUTICS INCAPGE · 2,330,651 shares | Other | SH | $175.9M | 3.1% |
| ROIVANT SCIENCES LTDROIV · 7,985,461 shares | Other | SH | $173.3M | 3.1% |
| NUVALENT INCNUVL · 1,665,105 shares | Other | SH | $167.5M | 3.0% |
| TRAVERE THERAPEUTICS INCTVTX · 4,278,180 shares | Other | SH | $163.5M | 2.9% |
| SPDR SERIES TRUST78464A870 · 1,100,000 underlying shares | Hedge | PUT | $134.1M | 2.4% |
| EXACT SCIENCES CORP30063P105 · 1,200,487 shares | Other | SH | $121.9M | 2.2% |
| PROTAGONIST THERAPEUTICS INCPTGX · 1,350,425 shares | Other | SH | $117.9M | 2.1% |
| INHIBRX BIOSCIENCES INCINBX · 1,452,707 shares | Other | SH | $114.8M | 2.0% |
| EDGEWISE THERAPEUTICSEWTX · 4,457,974 shares | Other | SH | $110.6M | 2.0% |
| IMMATICS N.VIMTX · 10,383,456 shares | Other | SH | $109M | 1.9% |
| SPYRE THERAPEUTICS INCSYRE · 3,069,225 shares | Other | SH | $100.5M | 1.8% |
| AMYLYX PHARMACEUTICALS INCAMLX · 8,284,882 shares | Semis | SH | $100.1M | 1.8% |
| ARCELLX INCACLX · 1,466,071 shares | Other | SH | $95.6M | 1.7% |
| VIRIDIAN THERAPEUTICS INCVRDN · 3,042,703 shares | Other | SH | $94.7M | 1.7% |
| BOSTON SCIENTIFIC CORPBSX · 979,000 shares | Other | SH | $93.3M | 1.7% |
| AMICUS THERAPEUTICS INCFOLD · 6,370,851 shares | Other | SH | $90.7M | 1.6% |
| ZYMEWORKS INCZYME · 3,261,850 shares | Other | SH | $85.9M | 1.5% |
| ASTRIA THERAPEUTICS INC04635X102 · 6,485,420 shares | Other | SH | $84.9M | 1.5% |
| MEIRAGTX HLDGS PLCMGTX · 10,326,103 shares | Other | SH | $82.1M | 1.5% |
| ARTIVION INCAORT · 1,722,290 shares | Other | SH | $78.6M | 1.4% |
| CENTESSA PHARMACEUTICALS PLCCNTA · 2,917,634 shares | Semis | SH | $73M | 1.3% |
| DYNE THERAPEUTICS INCDYN · 3,478,944 shares | Other | SH | $68M | 1.2% |
| NURIX THERAPEUTICS INCNRIX · 3,555,877 shares | Other | SH | $67.5M | 1.2% |
| SOLID BIOSCIENCES INCSLDB · 11,833,539 shares | Other | SH | $66.7M | 1.2% |
| BELITE BIO INCBLTE · 414,239 shares | Other | SH | $66.3M | 1.2% |
| ABIVAX SAABVX · 458,343 shares | Other | SH | $61.8M | 1.1% |
| INVIVYD INCIVVD · 21,785,166 shares | Other | SH | $53.8M | 0.96% |
| ENGENE HOLDINGS INCENGN · 5,869,076 shares | Other | SH | $53M | 0.94% |
| REPLIGEN CORPRGEN · 315,541 shares | Other | SH | $51.7M | 0.92% |
| IMMUNOVANT INCIMVT · 1,994,890 shares | Other | SH | $50.7M | 0.90% |
| INTUITIVE SURGICAL INCISRG · 87,919 shares | Other | SH | $49.8M | 0.89% |
| SIONNA THERAPEUTICS INCSION · 1,179,098 shares | Other | SH | $48.5M | 0.86% |
| NEUROCRINE BIOSCIENCES INCNBIX · 331,050 shares | Other | SH | $47M | 0.84% |
| DANAHER CORPORATIONDHR · 200,000 shares | Other | SH | $45.8M | 0.82% |
| ORUKA THERAPEUTICS INCORKA · 1,476,501 shares | Other | SH | $44.8M | 0.80% |
| CYTOMX THERAPEUTICS INCCTMX · 9,680,185 shares | Other | SH | $41.2M | 0.74% |
| OMADA HEALTH INCOMDA · 2,396,330 shares | Other | SH | $37.8M | 0.67% |
| CIDARA THERAPEUTICS INC171757206 · 165,131 shares | Other | SH | $36.5M | 0.65% |
| DISC MEDICINE INCIRON · 450,743 shares | Other | SH | $35.8M | 0.64% |
| BRIGHT MINDS BIOSCIENCES INCDRUG · 449,290 shares | Other | SH | $35.1M | 0.62% |
| PENUMBRA INCPEN · 110,529 shares | Other | SH | $34.4M | 0.61% |
| ALTO NEUROSCIENCE INCANRO · 1,784,393 shares | Other | SH | $31.8M | 0.57% |
| CARIS LIFE SCIENCES INCCAI · 1,136,206 shares | Other | SH | $30.7M | 0.55% |
| JAZZ PHARMACEUTICALS PLCJAZZ · 170,000 shares | Semis | SH | $28.9M | 0.52% |
| PALISADE BIO INCPALI · 12,050,000 shares | Other | SH | $28.3M | 0.50% |
| RAPT THERAPEUTICS INC75382E208 · 825,890 shares | Other | SH | $28M | 0.50% |
| PALVELLA THERAPEUTICS INC NEPVLA · 266,287 shares | Other | SH | $27.9M | 0.50% |
| AXSOME THERAPEUTICS INCAXSM · 148,900 shares | Other | SH | $27.2M | 0.48% |
| AXOGEN INCAXGN · 784,140 shares | Other | SH | $25.7M | 0.46% |
| X4 PHARMACEUTICALS INCXFOR · 6,314,452 shares | Semis | SH | $25.3M | 0.45% |
| BIOCRYST PHARMACEUTICALS INCBCRX · 3,162,529 shares | Semis | SH | $24.7M | 0.44% |
| NAUTILUS BIOTECHNOLOGY INCNAUT · 12,594,211 shares | Other | SH | $24.6M | 0.44% |
| KODIAK SCIENCES INCKOD · 848,900 shares | Other | SH | $23.7M | 0.42% |
| BIOGEN INCBIIB · 124,000 shares | Other | SH | $21.8M | 0.39% |
| ALDEYRA THERAPEUTICS INCALDX · 4,185,632 shares | Other | SH | $21.7M | 0.39% |
| ORCHESTRA BIOMED HLDGS INCOBIO · 5,127,256 shares | Other | SH | $21.3M | 0.38% |
| MIRUM PHARMACEUTICALS INCMIRM · 259,545 shares | Semis | SH | $20.5M | 0.37% |
| RAPPORT THERAPEUTICS INCRAPP · 673,923 shares | Other | SH | $20.4M | 0.36% |
| GRAIL INCGRAL · 237,342 shares | Other | SH | $20.3M | 0.36% |
| IRHYTHM TECHNOLOGIES INCIRTC · 108,000 shares | Other | SH | $19.2M | 0.34% |
| BETA BIONICS INCBBNX · 602,944 shares | Other | SH | $18.4M | 0.33% |
| CVS HEALTH CORPCVS · 220,000 shares | Other | SH | $17.5M | 0.31% |
| CONTINEUM THERAPEUTICS INCCTNM · 1,464,592 shares | Other | SH | $16.7M | 0.30% |
| GUARDANT HEALTH INCGH · 160,000 shares | Other | SH | $16.3M | 0.29% |
| ADMA BIOLOGICS INCADMA · 883,468 shares | Other | SH | $16.1M | 0.29% |
| RELAY THERAPEUTICS INCRLAY · 1,903,245 shares | Other | SH | $16.1M | 0.29% |
| GLAUKOS CORPGKOS · 140,000 shares | Other | SH | $15.8M | 0.28% |
| DEXCOM INCDXCM · 225,758 shares | Other | SH | $15M | 0.27% |
| SAVARA INCSVRA · 2,400,000 shares | Other | SH | $14.5M | 0.26% |
| CELCUITY INCCELC · 6,500,000 shares | Other | PRN | $14.1M | 0.25% |
| ATHIRA PHARMA INC04746L203 · 1,859,322 shares | Semis | SH | $14.1M | 0.25% |
| SEPTERNA INCSEPN · 433,160 shares | Other | SH | $12.1M | 0.22% |
| INHIBIKASE THERAPEUTICS INCIKT · 5,421,568 shares | Other | SH | $11.1M | 0.20% |
| ADAGIO MED HLDGS INC00534B100 · 9,876,576 shares | Other | SH | $10.3M | 0.18% |
| OCULIS HOLDING AGOCS · 493,827 shares | Other | SH | $9.9M | 0.18% |
| GOSSAMER BIO INCGOSS · 3,139,669 shares | Other | SH | $9.7M | 0.17% |
| MAPLIGHT THERAPEUTICS INCMPLT · 550,000 shares | Other | SH | $9.7M | 0.17% |
| XENON PHARMACEUTICALS INCXENE · 200,791 shares | Semis | SH | $9M | 0.16% |
| OPUS GENETICS INCIRD · 4,325,000 shares | Other | SH | $8.7M | 0.15% |
| ANTERIS TECHNOLOGIES GLOBALAVR · 1,675,476 shares | Other | SH | $8.4M | 0.15% |
| KESTRA MED TECHNOLOGIES LTDG52441105 · 285,000 shares | Other | SH | $7.6M | 0.13% |
| CAPRICOR THERAPEUTICS INCCAPR · 242,100 underlying shares | Other | CALL | $7M | 0.12% |
| BILLIONTOONE INCBLLN · 72,812 shares | Other | SH | $6M | 0.11% |
| BIOHAVEN LTDBHVN · 500,000 underlying shares | Other | CALL | $5.6M | 0.10% |
| KYMERA THERAPEUTICS INCKYMR · 69,935 shares | Other | SH | $5.4M | 0.10% |
| PEPGEN INCPEPG · 829,870 shares | Other | SH | $5.4M | 0.10% |
| CRESCENT BIOPHARMA INC.CBIO · 453,686 shares | Semis | SH | $5.4M | 0.10% |
| TENAX THERAPEUTICS INCTENX · 439,142 shares | Other | SH | $5.4M | 0.10% |
| CORVUS PHARMACEUTICALS INCCRVS · 692,441 shares | Semis | SH | $5.3M | 0.10% |
| TECTONIC THERAPEUTIC INCTECX · 250,000 underlying shares | Other | CALL | $5.2M | 0.09% |
| AQUESTIVE THERAPEUTICS INCAQST · 747,193 shares | Other | SH | $4.8M | 0.09% |
| TANGO THERAPEUTICS INCTNGX · 513,035 shares | Other | SH | $4.5M | 0.08% |
| KRYSTAL BIOTECH INCKRYS · 17,500 shares | Other | SH | $4.3M | 0.08% |
| COGENT BIOSCIENCES INCCOGT · 121,082 shares | Other | SH | $4.3M | 0.08% |
| OLEMA PHARMACEUTICALS INCOLMA · 165,713 shares | Semis | SH | $4.1M | 0.07% |
| SCHRODINGER INCSDGR · 202,400 shares | Other | SH | $3.6M | 0.06% |
| OUTSET MED INCOM · 833,333 shares | Other | SH | $3.1M | 0.06% |
| SAB BIOTHERAPEUTICS INCSABS · 803,210 shares | Other | SH | $3M | 0.05% |
| AVALO THERAPEUTICS INCAVTX · 139,667 shares | Other | SH | $2.5M | 0.05% |
| CONNECT BIOPHARMA HLDGS LTDCNTB · 792,696 shares | Semis | SH | $2.2M | 0.04% |
| IMMIX BIOPHARMA INCIMMX · 338,941 shares | Semis | SH | $1.8M | 0.03% |
| LEXEO THERAPEUTICS INCLXEO · 139,835 shares | Other | SH | $1.4M | 0.02% |
| CUMBERLAND PHARMACEUTICALS ICPIX · 341,087 shares | Semis | SH | $1.4M | 0.02% |
| MEDLINE INCMDLN · 28,000 shares | Other | SH | $1.2M | 0.02% |
| PALATIN TECHNOLOGIES INCPTNT · 70,000 shares | Other | SH | $1.1M | 0.02% |
| LENZ THERAPEUTICS INCLENZ · 50,000 shares | Other | SH | $800K | 0.01% |
| BIODESIXBDSX · 108,694 shares | Other | SH | $739.1K | 0.01% |
| ENVVENO MEDICAL CORPORATIONNVNO · 1,759,035 shares | Other | SH | $564.3K | 0.01% |
| IOVANCE BIOTHERAPEUTICS INCIOVA · 152,714 shares | Other | SH | $416.9K | 0.01% |
| REVOLUTION MEDICINES INCRVMD · 250,000 shares | Other | SH | $235K | 0.00% |
| ENSYSCE BIOSCIENCES INCENSC · 86,666 shares | Other | SH | $79.7K | 0.00% |
| SURROZEN INCSRZN · 166,666 shares | Other | SH | $3.3K | 0.00% |
Quarter tape
Signal breakdown
13F value is 1.35x the first tracked filing.
Top ten public lines are 41.8% of the latest report.
116 reportable lines in the latest public filing.
8 tracked quarterly 13F reports in the database or seed layer.
Publisher mode
Evidence layer
13F reports disclose long reportable U.S. securities and long put/call options. They do not show cash, private stakes, shorts, written options, or current live holdings.
Theme tags are deterministic product analysis from issuer, CUSIP, option type, and keyword rules. They are not SEC labels.
Vercel Cron calls the EDGAR ingestion endpoint every day and records per-manager ingestion results.
